MEMORY            °

* New one. Not Alzheimer, not Parkinson. Named LATE and very common. But: "If LATE is indeed as common as this research suggests, it may be necessary to develop new diagnostic tools to identify it in living patients and explore targeted therapies that can prevent or slow the buildup of TDP-43 protein in the brain. Moreover, the high prevalence of LATE in this population underscores the need for a more holistic approach to brain health in old age. Rather than focusing on a single disease like Alzheimer’s, future strategies may need to address multiple aspects of brain aging simultaneously to effectively combat cognitive decline."

* Let's realize first. “Around a generation ago, we assumed that when we get older, we dramatically lose our memory. That's really not the case.” The brain’s gradual, slow decline is really gradual, really slow, and really shallow. During healthy aging, volume and number of neurons in the brain decrease, as does the amount of insulation around them, called myelin. As we become more, let’s say, sophisticated, our processing speed typically slows, but our decision-making is wiser and our loss of memory power is subtle." Sharon Sha, clinical professor of neurology & neurological sciences, Stanford.

* Combat Alzheimer with Espressos! "We have presented a large body of evidence that espresso coffee . . . is a source of natural compounds showing beneficial properties in ameliorating tau-related pathologies."
* Blood test dementia risk.
* Combat dementia with your sense of Smell! "Smell training!"
* Combat dementia with music!"Powerful!"
* Combat Alzheimer with [Real] Wasabi !
"Boosts Cognitive Ability"
* New study, 11 factors key to reducing dementia risk by 40%. (2023)

* Curiosity: Thought Exercises.

* 6 ways to slow memory decline.
* Deep sleep fights memory decline.

* Curable form of dementia.

* Youngest case ever reported. Age 19.

* Stroke recovery.

* Your memory HIV drug helps.

* Also, Walk backwards-1 & Backwards-2.

* Keep your brain active! Active.

* Seafood for brain Sea.

More:

Foods (Chicago study/U Illinois starring roles)
TEDx talk video.

Music/Vibration therapy
TEDx talk video. Sound at a cellular level.

Ibuprofen
Paper suggests daily dose of ibuprofen could help prevent Alzheimer’s disease. (2018)
But another study found it does not slow cognitive decline.

To help prevent cognitive decline
Neuroscientists snack on: Blueberries, Walnuts, Almonds, Wasabi, Kale chips, Smoked salmon, Sardines. (2023)

°    DRAMATIC RESEARCH     °

* Alzheimer. Two totally new weapons: synthesized molecules. One from Ben Gurion U. One from UCLA.
* Totally new thinking:
- Not a brain disease!
- Dysfunctional mitochondria (energy factories in every brain cell).
- Bacterial infection (likely from mouth).
- Metals (abnormal handling of metals within brain).
* New cancer inhibitor drugs:
act against Alzheimer.
* Alzheimer < > viruses. 500k med records.
* New approach to tradtional enemy: toxic protein clumps. New theory about this enemy: PLD3 Lysosomes Axons.


A way forward. Long-term memory discovery.      Brand new drug approvals, lecanemab and aducanumab, have received much attention, but one source (newscientist.com - subscription required) wrote recently: "FOR the first time in nearly two decades, a new treatment for Alzheimer’s disease was approved by the US Food and Drug Administration in June. But instead of joy and relief, the announcement was largely met with frustration and even anger."
     Even newer donanemab, on verge of approval summer 2023, may hold even greater potential. Donanemab 7-2023.
Drug Screening Research: Oxford.

Key area of research: gut-microbiome (2023).
Further proof gut health is key: based on studies using identical twins over age 60, one of whom got a cheap supplement, inulin, found in chicory, or FOS,mainly used as low-cal sweetner (pre-and-probiotics), significantly improved cognitive results compared to other twin (2024).

Giving people functions back: Dementia et al.

* Another new theory: Breakthrough? Ethnobotany. (2019) "In a small lab in Jackson Hole, Wyo., 65-year-old Paul Cox believes he’s closing in on a treatment that might prevent Alzheimer’s disease. And ALS. And a host of other neurodegenerative diseases, for that matter. Cox, we should point out, isn’t a neurologist. He isn’t a physician of any kind."
"Our unusual tale begins with ethnobotany: the study of the way indigenous people use plants in their customs and diet. You see, Cox is an ethnobotanist, and a darn good one by all accounts. “You’d enjoy walking through a jungle with me,” he once told me."
"Chamorro were up to 100 times as likely as people elsewhere in the world to develop symptoms often associated with neurodegenerative diseases like ALS, Alzheimer’s, and Parkinson’s: slurred speech, facial paralysis, loss of motor skills, immobility and dementia. Believing that this cluster might hold essential clues to neurodegeneration, scientists advanced several theories. Some targeted a toxin found in the seeds of local cycad trees. Called BMAA, it killed nerve cells in lab tests and induced symptoms of lytico-bodig when fed to monkeys."

Chamorro 1819. "Cyanobacteria, which are often referred to as bluegreen algae, are all around us, in oceans and lakes, in puddles and ponds, even under the crust of deserts from Kuwait to Arizona. And cyanobacteria are loaded with toxins, including BMAA."


* Tohoku University study links dental hygiene to Alzheimer.

More generally:

* New way to slow aging: transposable elements.